Indeed, the essential oil of rosescented geranium leaves was prepared and their antioxidant activities as well as their hypoglycemic effects were studied. Biochemical and haematological effects of the leaf extract. Red kidney beans was investigated for its effects in alloxan induced diabetic rats. This study evaluated the longterm effects of alloxan induced diabetes in rat liver. Cronicon open access ec pharmacology and toxicology. Alloxan diabetic rats were orally supplied with kombucha and black tea at a dose of 5 mlkg body weight per day for 30 days, fasted overnight.
Raw camel milk properties on alloxaninduced diabetic. Diabetes was induced with administration of alloxan, 150 mgkg body weight i. View the article pdf and any associated supplements and figures for a period of 48 hours. Marked degenerations of the islets of langerhans was observed in pancreas of alloxan induced diabetic rats, whereas, histological examination of the pancreas of. Silymarin increases antioxidant enzymes in alloxan induced diabetes in rat pancreas. Glycemic effect of honey on alloxaninduced diabetes and with concomitant administration of fructose was studied in male rats of the wistar strain. The animals were distributed into 4 groups of 5 rats each namely. Alloxan is a toxic glucose analogue, which selectively destroys insulinproducing cells in the pancreas that is, beta cells when administered to rodents and many other animal species.
The experimental animals were grouped into five groups ae of. Group a served as the control and received 1 mlkg body weight of 5% ethanol being solvent used, group b received 1 ml alloxan. Blood glucose level and lipid profile of alloxaninduced. The test group was treated with 200 mgkg dosage of moringa oleifera ethanolic leave extract. Antihyperglycemic and antihyperlipidemic activity of. Diabetes was induced in wistar rats by single intraperitoneal administration of alloxan monohydrate 150 mgkg. Indeed, in rat islets incubated with alloxan the gsh content and gshgssg ratio were decreased malaisse et al. The purpose of this study is to evaluate the effect of ethanolic extract of cherry fruit on alloxan induced diabetic rats. Alloxan diabetes was induced into 20 rats and the rats weighed 125g. The present study aimed to investigate and compare the hypoglycemic and antilipidemic effects of kombucha and black tea, two natural drinks commonly consumed around the world, in surviving diabetic rats. Pdf silymarin increases antioxidant enzymes in alloxan.
This study aims to investigate the therapeutic effects of the aqueous extract of clitoria ternatea linn. It has been successfully induced in a variety of animal species. Normal as well as diabetic rats were divided into groups n6 receiving different treatments. After 48 h, rats with fasting blood glucose levels of 200 mgdl and above were considered diabetic and used for the study. Effect of luffa aegyptica leaf extract on blood sugar level in alloxan induced diabetic rats. The effect of orally administered aqueous extracts 400 mgkg body weight of clitoria ternatea leaves and flowers on serum glucose, glycosylated hemoglobin, and insulin were examined in control and extract. The study was conducted to evaluate effect of doum fruit extract on some biochemical parameters, including enzyme activities and histopathological changes of pancreas in alloxan induced diabetic rats. Alloxaninduced diabetes is a form of insulindependent diabetes mellitus that occurs as a result of alloxan administration or injection to animals.
Analysis of certain biochemical indices on alloxan induced. In the in vivo experiment, glucose given to rats 20 min prior to alloxan partially restricted alloxan induced increase in the activity of glutathione peroxidase. Fresh leaves of the plant were collected from their local habitat in the university of nigeria, nsukka environment. Diabetes was induced in wistar rats n 25 by intravenous administration of alloxan 42 mgkg and were analyzed at 1, 3, 6, 9 and 12 months after diabetes induction. Fabaceae leaves and flowers on alloxan induced diabetes in rats. This causes an insulindependent diabetes mellitus called alloxan diabetes in these animals, with characteristics similar to type 1 diabetes in humans. Twenty four albino rats were randomly allocated into four groups ad of six rats each such that group a diabetes control received 0. Rats with blood glucose levels above 250 mgdl were considered diabetic 30 and selected for the study. Alloxaninduced diabetic thermal hyperalgesia, prophylaxis. The present study is aimed to gain an insight about the effects of ethanolic extract of boerhavia diffusa l roots against alloxan induced diabetic rats. Anticoagulant activity of averrhoa bilimbi linn in normal. Induction of diabetes mellitus alloxan monohydrate was used to induce diabetes mellitus. Antidiabetic activity of hibiscus syriacus on alloxan induced diabetic rats kanjeri nirosha 1, m.
Antidiabetic effect of ipomoea batatas in normal and. Anti diabetic and hypolipidaemic properties of ginger zingiber officinale in streptozotocin induced diabetic rats volume 96 issue 4 zainab m. Alloxan was injected into the rats through a tail artery and three days later, a confirmation of successful induction of diabetes was made by demonstration of hyperglycemia in the rats. Antidiabetic and hypolipidaemic properties of ginger. Streptozotocin use in mice and rats version 1 date of publication. The rats are divided into 6 groups and each group con tains 6 rats n 6 as follows. Anti diabetic effect of cherries in alloxan induced. The anti diabetic activity of murva may be by any one of the above said mechanism or by both this mechanism and so might be of value in diabetes treatment. Effect of dme on alloxan induced diabetic rats a total of twenty five 25 diabetic and five 5 normoglycemic rats of both sexes were used. Alloxan induced diabetic thermal hyperalgesia, prophylaxis and phytotherapeutic effects of rheum ribes l. G1 normal rats fed on normal diet, g2 diabetic rats fed on normal diet, and g3 diabetic rats were fed with raw camel milk. Phytochemical composition of the herbal extracts, fasting plasma glucose concentration fpgc, and serum. Alloxan monohydrate is used to induce diabetes mellitus in albino rats in the dose of 120mgkg i.
Hypoglycemic and antilipidemic properties of kombucha tea. The present study was carried out to evaluate the antidiabetic effect of psidium guajava leaves extract and to study the activities of hexokinase, aldolase and phosphor glucoisomerase, and gluconeogenic enzymes such asglucose6phosphatase and. In the alloxan induced diabetic rats showed that extract at 500 mgkg decreased significantly fasting plasma glucose level by 61. Thirty 30 adults male wistar rats were randomly divided into six 6 groups of five 5 each based on their body weight. Pooja 1, mohemmed sadiq 2 1sree vidyanikethan college of pharmacy, sree sainath nagar, tirupati, a. Alloxaninduced diabetes, a common model for evaluating. The herbal formulation known as herbamed was administered to diabetic rats for 7 days at 0. The effects of alloxan on the histology of the pancreas. Effect of doum fruit hyphaene thebaica extract on some. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal, intravenous and. The alloxan induced diabetic rats were grouped into three groups containing at least 5 rats in each group. Antihyperglycemic and antihyperlipidemic effect of. Diabetes was induced in wistar albino rats by intraperitoneal injection of alloxan 120 mgkg bw once. Studies on the administration of vernonia amygdalina del.
Medicinal plants have been used in the treatment of some diseases like diabetes. Antidiabetic drugs in combination with hydroxychloroquine. Diabetes was induced in male wistar rats by the administration of alloxan monohydrate at 100 mgkg of body weight. Cagle university of tennessee knoxville this thesis is brought to you for free and open access by the graduate school at trace. The induction of diabetes was confirmed after the 5th day of alloxan treatment by. Diabetes was induced by administering a single dose of alloxan 120 mgkg. Research article alloxan induced diabetes mellitus in. The rats randomly selected were divided into six 6 groups of five 5 rats per group. Antidiabetic and antioxidant activities of the methanol. In the light of the above data, the objectives of the present study were to evaluate the effect of hcq on blood glucose and lipid profile in alloxan induced diabetic rats and to study its effect on the above parameters in com bination with conventional oral antidiabetic agents. Alloxan has been administered in single or multiple doses, through different routes intraperitoneal, intravenous and subcutaneous.
Thirty nondiabetic control rats nc and 30 untreated diabetic ud rats were divided into three subgroups sacrificed after 6, 14, or 26 weeks. The hemimandibles were removed and submitted to radiographical and histopathological procedures. Hypoglycemic and antioxidant effects of leaf essential oil. Alloxan and streptozotocin are the most prominent diabetogenic chemicals in diabetes research.
Antidiabetic activity of hibiscus syriacus on alloxan. Antidiabetic activity of leaves of jatropha curcus l. Rats were administered 200 mgkgday and 500 mg kgday p. After an overnight fast, the rats were injected single dose 125mgkg of freshly prepared 5% solution of alloxan monohydrate in 0. Graded doses 200 mgkg and 400 mgkg of ethanol extract of plectranthus amboinicus were studied in both normal and alloxan induced. Antidiabetic activity of aqueous extract of cinnamomum. Although their cytotoxicity is achieved via different pathways, their mechanisms of beta cell selective action are identical. The mechanism of alloxan and streptozotocin action in b. Aqueous extract of maerua oblongifolia rootst exhibited significant antihyperglycemic activities in alloxan induced diabetic rats. Original article rat model of foodinduced nonobesetype.
The effect of aepe leaf extract on blood glucose, insulin, hemoglobin and glycosylated hemoglobin, serum lipid profile, liver glycogen and protein were measured in the diabetic rats. Anion gap toxicity in alloxan induced type 2 diabetic rats. The effects of alloxan on the histology of the pancreas, thyroid and adrenal glands of the white rat julien l. Alloxan 150mgkg was used to induce diabetes in rats and the blood glucose levels were estimated by using glucometer. Alloxaninduced diabetes triggers the development of. Diabetes was induced by intra peritoneal injection of 120 mgkg alloxan. Hence, the present study undertakes the investigation of possible hypoglycemic and antioxidant effects of pelargonium graveolens leaves in alloxan induced diabetic rats. In this study 36 male wistar rats, body weight of 150200gr were divided into 6 groups.
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